Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome
Identifieur interne : 003885 ( Main/Exploration ); précédent : 003884; suivant : 003886Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome
Auteurs : Yoshio Tsuboi [Japon] ; Keith A. Josephs [États-Unis] ; Bradley F. Boeve [États-Unis] ; Irene Litvan [États-Unis] ; Richard J. Caselli [États-Unis] ; John N. Caviness [États-Unis] ; Ryan J. Uitti [Japon] ; Allen D. Bott [États-Unis] ; Dennis W. Dickson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-08.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Alzheimer disease, Alzheimer's disease, Brain (metabolism), Brain (pathology), Diagnostic Imaging (methods), Female, Humans, Male, Middle Aged, Nervous system diseases, Neurodegenerative Diseases (etiology), Neurodegenerative Diseases (metabolism), Neurodegenerative Diseases (pathology), Statistics, Nonparametric, Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (metabolism), Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (physiopathology), asymmetrical features, corticobasal syndrome, progressive supranuclear palsy, tau Proteins (metabolism), tau burden.
- MESH :
- chemical , metabolism : tau Proteins.
- complications : Supranuclear Palsy, Progressive.
- etiology : Neurodegenerative Diseases.
- metabolism : Brain, Neurodegenerative Diseases, Supranuclear Palsy, Progressive.
- methods : Diagnostic Imaging.
- pathology : Brain, Neurodegenerative Diseases, Supranuclear Palsy, Progressive.
- physiopathology : Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
The objective of this study is to better define the pathological characteristics of pathologically proven progressive supranuclear palsy (PSP) presenting with the corticobasal syndrome (CBS). PSP is characterized by early falls, vertical supranuclear ophthalmoplegia, and axial rigidity, whereas asymmetric limb features, including rigidity, bradykinesia, apraxia, alien limb phenomena, and cortical sensory loss are characteristic of CBS. We investigated clinicopathological characteristics of 5 cases of PSP that presented with CBS (CBS‐PSP). Comprehensive pathological analysis was undertaken to determine the presence of concomitant pathological processes as well as quantitative tau burden in cortical regions of CBS‐PSP, compared with 8 typical PSP cases (Typ‐PSP). The clinical features in the CBS‐PSP cases included asymmetrical features, apraxia, alien limb phenomena, and progressive aphasia. All cases had Parkinsonism, and vertical supranuclear ophthalmoplegia was noted in all but 1 case of CBS‐PSP. Secondary neuropathological diagnoses included argyrophilic grain disease (AGD) in 1 of the 8 cases of Typ‐PSP, whereas Alzheimer's disease (AD), Lewy body disease, AGD, and vascular disease was found in 3 cases of CBS‐PSP. Image analysis of cortical tau burden performed in 8 Typ‐PSP and 3 CBS‐PSP cases revealed a significant increased tau burden in mid‐frontal and inferior‐parietal cortices in the CBS‐PSP cases. This study demonstrates that when PSP presents as CBS, it is most likely due to either a concurrent cortical pathology from a secondary process such as AD or from the primary pathology of PSP extending into cortical areas that are primarily and commonly affected in CBD. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20478
Affiliations:
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Dickson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-08">2005-08</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="982">982</biblScope><biblScope unit="page" to="988">988</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">25E834F04F5F4CE97886875436ABE1A8D0F0D35C</idno><idno type="DOI">10.1002/mds.20478</idno><idno type="ArticleID">MDS20478</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alzheimer disease</term><term>Alzheimer's disease</term><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Diagnostic Imaging (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neurodegenerative Diseases (etiology)</term><term>Neurodegenerative Diseases (metabolism)</term><term>Neurodegenerative Diseases (pathology)</term><term>Statistics, Nonparametric</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Supranuclear Palsy, Progressive (metabolism)</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>asymmetrical features</term><term>corticobasal syndrome</term><term>progressive supranuclear palsy</term><term>tau Proteins (metabolism)</term><term>tau burden</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Neurodegenerative Diseases</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Neurodegenerative Diseases</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence Alzheimer</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study is to better define the pathological characteristics of pathologically proven progressive supranuclear palsy (PSP) presenting with the corticobasal syndrome (CBS). PSP is characterized by early falls, vertical supranuclear ophthalmoplegia, and axial rigidity, whereas asymmetric limb features, including rigidity, bradykinesia, apraxia, alien limb phenomena, and cortical sensory loss are characteristic of CBS. We investigated clinicopathological characteristics of 5 cases of PSP that presented with CBS (CBS‐PSP). Comprehensive pathological analysis was undertaken to determine the presence of concomitant pathological processes as well as quantitative tau burden in cortical regions of CBS‐PSP, compared with 8 typical PSP cases (Typ‐PSP). The clinical features in the CBS‐PSP cases included asymmetrical features, apraxia, alien limb phenomena, and progressive aphasia. All cases had Parkinsonism, and vertical supranuclear ophthalmoplegia was noted in all but 1 case of CBS‐PSP. Secondary neuropathological diagnoses included argyrophilic grain disease (AGD) in 1 of the 8 cases of Typ‐PSP, whereas Alzheimer's disease (AD), Lewy body disease, AGD, and vascular disease was found in 3 cases of CBS‐PSP. Image analysis of cortical tau burden performed in 8 Typ‐PSP and 3 CBS‐PSP cases revealed a significant increased tau burden in mid‐frontal and inferior‐parietal cortices in the CBS‐PSP cases. This study demonstrates that when PSP presents as CBS, it is most likely due to either a concurrent cortical pathology from a secondary process such as AD or from the primary pathology of PSP extending into cortical areas that are primarily and commonly affected in CBD. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Arizona</li><li>Colorado</li><li>Floride</li><li>Kentucky</li><li>Minnesota</li></region></list><tree><country name="Japon"><noRegion><name sortKey="Tsuboi, Yoshio" sort="Tsuboi, Yoshio" uniqKey="Tsuboi Y" first="Yoshio" last="Tsuboi">Yoshio Tsuboi</name></noRegion><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name></region><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F." last="Boeve">Bradley F. Boeve</name><name sortKey="Bott, Allen D" sort="Bott, Allen D" uniqKey="Bott A" first="Allen D." last="Bott">Allen D. Bott</name><name sortKey="Caselli, Richard J" sort="Caselli, Richard J" uniqKey="Caselli R" first="Richard J." last="Caselli">Richard J. Caselli</name><name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N." last="Caviness">John N. Caviness</name><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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